Degradación de ácido poliláctico/hidroxiapatita y ácido poliglicólico en fluido corporal simulado
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Universidad Industrial de Santander
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El presente trabajo de investigación presenta la degradación de materiales compuestos de ácido poliláctico, ácido poliglicólico e hidroxiapatita en un electrolito de solución fisiológica simulada, fue evaluada mediante electroquímica y microbalanza de cristal de cuarzo. Los materiales fueron obtenidos a diferentes concentraciones y electrodepositados catódicamente sobre cristales de cuarzo piezoeléctricos para formar películas delgadas. Los cristales recubiertos fueron sumergidos durante 1, 3, 5, 7 y 10 días en fluido corporal simulado a temperatura y pH constantes y en cada intervalo se realizaron análisis de espectroscopia de impedancia electroquímica y microbalanza de cristal de cuarzo que permitieron relacionar los cambios de frecuencia de la microbalanza con la carga eléctrica total transferida durante el proceso de degradación.
In this work the degradation of composites of polylactic acid, polyglycolic acid and hydroxyapatite in a simulated physiological electrolyte solution was evaluated by electrochemical quartz crystal microbalance. The materials were obtained at different concentrations and cathodically electrodeposited on piezoelectric quartz crystals to form thin films. Coated crystals were immersed for 1, 3, 5, 7 and 10 days in simulated body fluid at temperature and pH constant at each interval analysis was performed Electrochemical Impedance Spectroscopy and Quartz Crystal Microbalance that allowed to relate the frequency change of the microbalance with the total electric charge transferred in the process of degradation.
In this work the degradation of composites of polylactic acid, polyglycolic acid and hydroxyapatite in a simulated physiological electrolyte solution was evaluated by electrochemical quartz crystal microbalance. The materials were obtained at different concentrations and cathodically electrodeposited on piezoelectric quartz crystals to form thin films. Coated crystals were immersed for 1, 3, 5, 7 and 10 days in simulated body fluid at temperature and pH constant at each interval analysis was performed Electrochemical Impedance Spectroscopy and Quartz Crystal Microbalance that allowed to relate the frequency change of the microbalance with the total electric charge transferred in the process of degradation.
Keywords
biomaterial, impedance, microbalance, hydrolytic degradation, biomateriales, impedancia, microbalanza, degradación hidrolítica