A Mechanism of crystallization process of hemoglobin S A Mechanism of crystallization process of hemoglobin S

No Thumbnail Available
Date
Authors
Cabal Mirabal, Carlos
Ruiz Chaveco, Ivan
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Industrial de Santander
Abstract
Description
 It has been studied as the qualitative consequence of a proposed mechanism of reaction for the formation of HbS molecular aggregations, as well as the mathematical model associated with it, for the particular case that the process of crystallization takes place at partial pressure and constant temperature. It is showed that the results mentioned in the study can be used to explain experimental existing data, although this data are small to decide between various options that are compatible with existing experimental models and experimental data. Also, qualitative consequences of to mechanism of reaction suggested for the formation of HbS molecular aggregations, as well as the mathematical model associated, are studied for a particular case in which to process of crystallization under constant oxygen, partial pressure and constant tem-peratures. The results of such study, which are able to explain the existing experi­mental data, are shown. However, this is latter very scarce for being able to decide among various existing choices compatible with the model and experimental data.  
It has been studied as the qualitative consequence of a proposed mechanism of reaction for the formation of HbS molecular aggregations, as well as the mathematical model associated with it, for the particular case that the process of crystallization takes place at partial pressure and constant temperature. It is showed that the results mentioned in the study can be used to explain experimental existing data, although this data are small to decide between various options that are compatible with existing experimental models and experimental data. Also, qualitative consequences of to mechanism of reaction suggested for the formation of HbS molecular aggregations, as well as the mathematical model associated, are studied for a particular case in which to process of crystallization under constant oxygen, partial pressure and constant tem-peratures. The results of such study, which are able to explain the existing experi­mental data, are shown. However, this is latter very scarce for being able to decide among various existing choices compatible with the model and experimental data.  
Keywords
Polymerization, Crystallization, HemoglobinS, Sickle-cell, Modeling
Citation