Potencial terapéutico de las células madre en la enfermedad cerebrovascular
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Universidad Industrial de Santander
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La enfermedad cerebrovascular es una importante causa de muerte e incapacidad en todo el mundo. Esta enfermedad es consecuencia de un complejo grupo de procesos fisiopatológicos que afectan la vasculatura del sistema nervioso, resultando en isquemia y modificaciones del metabolismo neuronal. Se ha demostrado que células neurales han ayudado a reparar los daños asociados a la enfermedad cerebrovascular en modelos animales y han conducido a mejoras en su capacidad física. Además, se ha observado que la aplicación endógena de células madre ocasiona neurogénesis espontánea en respuesta a la lesión isquémica y se puede mejorar a través de una adecuada infusión de citoquinas. En esta revisión se analizan diversos aspectos de la potencial aplicación de las células madre como estrategia terapéutica en el manejo de la enfermedad cerebrovascular.
Palabras clave: Células madre. Enfermedad cerebrovascular. Ictus. Cerebro.
Therapeutic potential of stem cells in Cerebrovascular Disease. Cerebrovascular disease is a major cause of death and disability in the worldwide, this disease results from a complex set of pathophysiologic processes that affect the nervous system vasculature, resulting in ischemia and changes in neuronal metabolism. It has been shown that neural cells helped repair damage associated with cerebrovascular disease in animal models and have led to improvements in physical capacity. Furthermore, it appears that the application of endogenous stem cells causes spontaneous neurogenesis in response to ischemic injury and can be improved through proper infusion of cytokines. This review discusses various aspects of the potential application of stem cells as a therapeutic strategy in the management of cerebrovascular disease. Key words: Stem cells. Cerebrovascular disease. Stroke. Brain.
Therapeutic potential of stem cells in Cerebrovascular Disease. Cerebrovascular disease is a major cause of death and disability in the worldwide, this disease results from a complex set of pathophysiologic processes that affect the nervous system vasculature, resulting in ischemia and changes in neuronal metabolism. It has been shown that neural cells helped repair damage associated with cerebrovascular disease in animal models and have led to improvements in physical capacity. Furthermore, it appears that the application of endogenous stem cells causes spontaneous neurogenesis in response to ischemic injury and can be improved through proper infusion of cytokines. This review discusses various aspects of the potential application of stem cells as a therapeutic strategy in the management of cerebrovascular disease. Key words: Stem cells. Cerebrovascular disease. Stroke. Brain.