Procaína, epigenética y terapia neural en el cáncer, ¿una alternativa terapéutica?
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Universidad Industrial de Santander
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Una marca distintiva del cáncer humano desde la epigenética es el silenciamiento de los genes supresores de tumores,junto con la hipermetilación del ADN. En esta revisión se describe como la procaína es capaz de producir modificaciónepigenética en cuatro estudios de cáncer in vitro e in vivo, y como cuando se combina con otros fármacos antineoplásicosaumenta el índice terapéutico mejorando la actividad antitumoral. De esta manera, el objetivo es exponer una visión deconjunto de datos seleccionados que muestran los avances de la investigación de la epigenética del cáncer, entendidacomo el estudio de los mecanismos reversibles que interactúan sobre el ADN, modificando la expresión de genes sin alterarla estructura genética. Así mismo, la utilidad de un medicamento, la procaína, un anestésico local en la desmetilacióndel ADN y la consecuente reexpresión de genes supresores de tumores, así como su posible aplicación en la clínica desdela óptica de la terapia neural, una terapéutica alternativa en la cual se coloca un estímulo inespecífico en el organismodel paciente para que él mismo busque autoorganizarse hacia un estado de salud. Para ello, se realizó una búsquedaelectrónica en Ágora, E-Libro, Ovid, Pubmed/Medline. (MÉD.UIS. 2011;24(2):165-71).Palabras clave: Procaína. Cáncer. Medicina alternativa. Metilación de ADN.
Procaine, epigenetics and neural therapy, a therapeutic alternative?A hallmark of human cancer from epigenetics is the silencing of tumor suppressor genes,along with DNA hypermethylation.This review describes procaine, which can produce epigenetic modification in four studies of cancer in vitro and in vivoand how, when combined with other anticancer drugs, increases the therapeutic index improving antitumor activity. Theaim of this review is to present a general perspective of selected data that shows the progress of the investigation ofcancer, defined as the study of reversible mechanisms interact on the DNA, altering gene expression without altering thestructure genetics epigenetics. In the same way, to explain an usefulness of a drug, procaine, a local anesthetic in thedemethylation of DNA and the consequent re-expression of tumor suppressor genes and its possible clinical applicationfrom the perspective of neural therapy, designed as a therapeutic alternative in that places a non-specific stimulationthe patient's body to locate itself self-organize into a state of health. For this, an electronic search of Agora, E-Book,Ovid, Pubmed / Medline, was conducted using this information for analysis.(MÉD.UIS. 2011;24(2):165-71).Key words: Procaine. Cancer. Alternative medicine. DNA Methylation.
Procaine, epigenetics and neural therapy, a therapeutic alternative?A hallmark of human cancer from epigenetics is the silencing of tumor suppressor genes,along with DNA hypermethylation.This review describes procaine, which can produce epigenetic modification in four studies of cancer in vitro and in vivoand how, when combined with other anticancer drugs, increases the therapeutic index improving antitumor activity. Theaim of this review is to present a general perspective of selected data that shows the progress of the investigation ofcancer, defined as the study of reversible mechanisms interact on the DNA, altering gene expression without altering thestructure genetics epigenetics. In the same way, to explain an usefulness of a drug, procaine, a local anesthetic in thedemethylation of DNA and the consequent re-expression of tumor suppressor genes and its possible clinical applicationfrom the perspective of neural therapy, designed as a therapeutic alternative in that places a non-specific stimulationthe patient's body to locate itself self-organize into a state of health. For this, an electronic search of Agora, E-Book,Ovid, Pubmed / Medline, was conducted using this information for analysis.(MÉD.UIS. 2011;24(2):165-71).Key words: Procaine. Cancer. Alternative medicine. DNA Methylation.