Relevancia clínica de las acciones tópicas de los opioides
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Universidad Industrial de Santander
Abstract
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Se trata de una práctica frecuente en algunos centros, es aún poca la evidencia que justifica el uso de formulaciones tópicas a base de un enfoque local en el tratamiento analgésico de condiciones dolorosas consiste en aplicar medicamentos localmente en el sitio de origen del dolor. Esto puede alcanzarse mediante la aplicación tópica de una crema, loción, gel, aerosol o parche para sitios somáticos o mediante la utilización de enjuagues en el caso de lesiones de la mucosa oral. Estos métodos de aplicación permiten una mayor concentración local del fármaco en el sitio de iniciación del dolor y disminuye los niveles sistémicos del fármaco a niveles mínimos o insignificantes, teóricamente disminuyendo el riesgo de efectos adversos sistémicos. El presente artículo pretende revisar información clínica y preclínica relevante para la prescripción de opioides tópicos.
Although it is a common practice in some centers, there is still little evidence that validates the use of topical analgesic formulations based on opioids for treatment painful skin and mucous conditions. A local focus on the analgesic treatment of painful conditions consists of applying drugs directly in the peripheral site of pain origin. This can be achieved through the topical application of a cream, lotion, gel, spray or patch for somatic sites or through the use of mouthwash in the case of lesions of the oral mucosa. These methods allow a greater local concentration of the drug at the painful site and decrease the systemic levels of the medication to minimum or negligible levels, theoretically reducing the risk of systemic adverse effects. This article aims to review relevant clinical and preclinical information on topical opioid prescribing.
Although it is a common practice in some centers, there is still little evidence that validates the use of topical analgesic formulations based on opioids for treatment painful skin and mucous conditions. A local focus on the analgesic treatment of painful conditions consists of applying drugs directly in the peripheral site of pain origin. This can be achieved through the topical application of a cream, lotion, gel, spray or patch for somatic sites or through the use of mouthwash in the case of lesions of the oral mucosa. These methods allow a greater local concentration of the drug at the painful site and decrease the systemic levels of the medication to minimum or negligible levels, theoretically reducing the risk of systemic adverse effects. This article aims to review relevant clinical and preclinical information on topical opioid prescribing.
Keywords
Analgesics, Opioid, Analgesia, Administration, Topica, Analgésicos Opioides, Analgesia, Administración Tópica