Escenciales en biología, patobiología y bioclínica del óxido nítrico
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Universidad Industrial de Santander
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El óxido nítrico es un regulador multifuncional, fundamental para diversos procesos incluyendo la infamación, vasoregulación, señalización intra e intercelular, apoptosis y carcinogénesis. La falla en la síntesis y/o la pérdida de la biodisponibilidad de óxido nítrico es la principal característica de muchas enfermedades. La comprensión de los mecanismos subyacentes a los efectos del óxido nítrico a nivel celular y tisular, permitirá el desarrollo de nuevas terapias para balancear los efectos del óxido nítrico in vivo. El objetivo de esta revisión es mencionar los principales hallazgos en el campo de investigación relativo a este gas diatómico y su dinámica biológica.
Palabras clave: Antioxidante. Especies reactivas del nitrógeno. Especies reactivas del oxígeno. Óxido nítrico. Señalamiento celular.
Nitric oxide is a multifunctional regulator, which is central to diverse processes including infammation, vasoregulation, intra-and intercellular signaling, apoptosis, and carcinogenesis. The failure in the synthesis and/or loss of bioavailability of nitric oxide is the main characteristic of many diseases. Understanding the mechanisms underlying the effects of nitric oxide at the cellular and tissue level, will allow the development of new therapies to balance the effects of nitric oxide in vivo. The purpose of this review is to mention the key findings in the feld of research on this diatomic gas and their biological dynamics. Key words: Antioxidant. Radical nitrogen species. Radical oxygen species. Nitric oxide. Cell signalling.
Nitric oxide is a multifunctional regulator, which is central to diverse processes including infammation, vasoregulation, intra-and intercellular signaling, apoptosis, and carcinogenesis. The failure in the synthesis and/or loss of bioavailability of nitric oxide is the main characteristic of many diseases. Understanding the mechanisms underlying the effects of nitric oxide at the cellular and tissue level, will allow the development of new therapies to balance the effects of nitric oxide in vivo. The purpose of this review is to mention the key findings in the feld of research on this diatomic gas and their biological dynamics. Key words: Antioxidant. Radical nitrogen species. Radical oxygen species. Nitric oxide. Cell signalling.